YES, the above comic is about dysentery. NO, I will not take the opportunity to make an Oregon Trail reference. And see there, I didn't even link to Oregon Trail, because that's how serious I am about this.
So go on, look it up on Wikipedia if you must, or examine one of the many T-shirts found online have images of old-timey wagons and the words "You have died of dysentery," heck, even buy one for all I care. But dear friends, I put it to you that you have not in fact died of dysentery, and be proud of that fact. Because you know what? You're still cool in my book.
Now if you will excuse me I'm going to play some Monkey Island.